4 edition of Effects of human milk and formula on the expression of intestinal xenobiotic transporters found in the catalog.
Effects of human milk and formula on the expression of intestinal xenobiotic transporters
Thesis (M.Sc.) -- University of Toronto, 2003.
|Series||Canadian theses = -- Thèses canadiennes|
|The Physical Object|
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However, a study with three human volunteers found that ampicillin increased members of the Bacteroidetes phyla (Maurice et al. ). Due to their selectivity of effect on the gut microbiome, antibiotics are being used for their efficacy to treat gut-microbiome-mediated diseases (Kerman and Deshpande ). Drug metabolism is the metabolic breakdown of drugs by living organisms, usually through specialized enzymatic systems. More generally, xenobiotic metabolism (from the Greek xenos "stranger" and biotic "related to living beings") is the set of metabolic pathways that modify the chemical structure of xenobiotics, which are compounds foreign to an organism's normal biochemistry, such as any drug.
The gastrointestinal (GI) system processes ingested milk into its molecular forms (digestion), ready for absorption and distribution by the circulatory system, as the larger macromolecules contained in milk are generally unable to cross the intestinal is achieved by the action of hydrochloric acid in the stomach, bile from the liver and a variety of digestive enzymes secreted. Human Milk Intestinal Epithelium Bovine Colostrum Breastfed Infant Mature Milk These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Xenobiotic biotransformation takes place in almost all organs and tissues (liver, skin, GI tract, lungs, kidney, blood, etc.); however, the liver is quantitatively the most important tissue for xenobiotic metabolism especially because of its high expression levels of many xenobiotic-metabolizing enzymes. ratios, and in vivo milk to serum ratios (M/S) and (3) to identify xenobiotic transporters that are highly expressed, and therefore potentially important for drug accumulation during lactation in mice and humans. Expression, localization, and functional assays confirmed that Abcg2 is the.
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Furthermore, the intestinal microbiota of breastfed infants was less diverse than that of formula-fed infants, but this lower alpha diversity in breastfed infants was consistent with the enrichment of genes required for the degradation of human milk oligosaccharides (HMOs) from breast milk.
16 The differences in the microbiome between breastfed Cited by: The study focused on the adverse health effect of xenobiotics which plays an important role in addressing public health challenge. The special issue has focused on the toxicity of xenobiotics. We call for manuscripts describing recent findings and future perspectives in the toxic field of xenobiotics on the human and animal by: 1.
Jernberg C, Lofmark S, Edlund C, Jansson JK. Long-term impacts of antibiotic exposure on the human intestinal microbiota. Microbiology. ; – Jochem FJ, Lavrentyev PJ, First MR.
Growth and grazing rates of bacteria groups with different apparent DNA content in the Gulf of Mexico. Mar Biol. ; –Cited by: The effect of diet, human milk or formula, on gastric function (lipase and pepsin activity, pH, and volume) and intragastric digestion of fat was assessed in 28 appropriate for gestational age Cited by: Tim J.
Evans DVM, MS, PhD, DACT, DABVT, in Small Animal Toxicology (Third Edition), Xenobiotic Storage Depots. Xenobiotics can be stored within a variety of different body organs and tissues. Depending on the anatomic and physiologic relationships between the storage depot and the target organs and tissues for a specific toxicant, storage of toxic xenobiotics can function as either a.
Antibiotics in milk and their effects on Human Health. Introduction. The presence of drug or antibiotic residues in milk and meat is illegal. of certain antimicrobial agents may significantly shift the resistance patterns in the microbial population in the human intestinal tract.
Antibiotics are known to interfere with the manufacture of. A xenobiotic is a chemical substance found within an organism that is not naturally produced or expected to be present within the organism. It can also cover substances that are present in much higher concentrations than are usual.
Also called as detoxification. Natural compounds can also become xenobiotics if they are taken up by another organism, such as the uptake of natural human hormones. In was further demonstrated that early human breast milk had an ability to suppress the expression of intestinal UGT1A1 in hUGT1 mice To investigate the effect of an oral glucose treatment on.
Maternal milk contains compounds that may affect newborn immunity. Among these are a group of oligosaccharides that are synthesized in the mammary gland from lactose; these oligosaccharides have been termed human milk oligosaccharides (HMOs).
The amount of HMOs present in human milk is greater than the amount of protein. In fact, HMOs are the third-most abundant solid component in. In neonatal hUGT1 mice, a diet of human breast milk maintains a state of severe hyperbilirubinemia, like what is seen with nursing neonatal hUGT1 mice (Fujiwara et al., ).
In hUGT1 mice, hepatic UGT1A1 expression is developmentally delayed, a major factor that leads to elevated TSB levels. In addition, intestinal UGT1A1 expression is also. A large number of nutrients and bioactive ingredients found in milk play an important role in the nourishment of breast-fed infants and dairy consumers.
Some of these ingredients include physiologically relevant compounds such as vitamins, peptides, neuroactive compounds and hormones. Conversely, milk may contain substances—drugs, pesticides, carcinogens, environmental. The breast milk influence on initial intestinal microbiota also prevents expression of immune-mediated diseases (asthma, inflammatory bowel disease, type 1.
The activity and the expression of several xenobiotic metabolizing enzymes were measured in subcellular fractions from the duodenal mucosa of male veal calves and beef cattle displaying a functional rumen but differing in both age (about 8 months vs.
18 to 24 months) and dietary regimens (i.e., milk replacer plus hay and straw vs. corn and. Abstract. Background: In the absence of human breast milk, infant and follow-on formulas can still promote efficient growth and development.
However, infant formulas can differ in their nutritional value. Objective: The objective of this study was to compare the effects of human milk (HM) and infant formulas in human infants and a weanling rat model. The human gut is packed with actively metabolizing microorganisms.
These have a transformative effect on what we ingest—whether food, drugs, or pollutants. Koppel et al.
review the distinguishing features of microbial xenobiotic metabolism, its interaction with somatic metabolism, and interindividual variation.
Depending on the functional composition of microorganisms in the gut, the. Feeding human milk, when compared with formulated milk, results in a better growth and maturation of the gastrointestinal tract. These beneficial effects can be attributed, at least in part to the unique composition of human milk.
• Intestinal disposition is critical for the bioavailability of orally administered compounds (but may not be the limiting factor) • Interactions with transporters/enzymes (modulation of expression and/or function) should be considered expression and/or function) should be considered •.
Minimal and full enteral feeding of infant formula or human milk has been shown to decrease the incidence of necrotizing enterocolitis and other gastrointestinal complications (Schanler et al., ; Commare and Tappenden, ; Neu, ), although a greater protective effect may be associated with human milk (Schanler et al., ).
Article Intrinsic Xenobiotic Resistance of the Intestinal Stem Cell Niche Graphical Abstract Highlights d Wnt-producing stromal cells of the intestine maintain the stem cell niche d Intestinal stromal cells are intrinsically resistant to drugs and toxins d This resistance is due in part to localized expression of drug efﬂux pumps d This adaptation protects the gut stem cell niche from.
Down-regulation of monocarboxylate transporter 1 (MCT1) gene expression in the colon of piglets is linked to bacterial protein fermentation and pro-inflammatory cytokine-mediated signalling - Volume Issue 4 - Carmen Villodre Tudela, Christelle Boudry, Friederike Stumpff, Jörg R. Aschenbach, Wilfried Vahjen, Jürgen Zentek, Robert Pieper.
Aims: To investigate the effect of prolonged consumption of a synbiotic milk (Synbiotic) containing Lactobacillus acidophilus (strain 74‐2, 10 7 CFU ml −1), Bifidobacterium lactis (strain10 7 CFU ml −1) and 2% inulin on colonic ecosystem in healthy humans.
Methods and Results: A group of 26 healthy subjects, aged 22–47 years, participated in a 6‐week placebo‐controlled.Intestinal P-glycoprotein (P-gp, ABCB1) may significantly influence drug absorption and elimination. Its expression and function is highly variable, regio-selective and influenced by genetic.This coordinate loss suggests that the expression of the drug resistance genes is driven by microenvironmental cues.
We speculate that one major evolutionary pressure on the function and expression of xenobiotic resistance mechanisms is the need to protect the microenvironment of the intestinal stroma from ingested toxins and microbial metabolites.